Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. In...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Picón-Pagès, Pol, Gutiérrez, Daniela A., Barranco-Almohalla, Alejandro, Crepin, Giulia, Tajes, Marta, ILL-Raga, Gerard, Guix, Francesc X., Menéndez, Silvia, Arumí-Uría, Montserrat, Vicente, Rubén, Álvarez, Alejandra R., Muñoz, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525306/
https://ncbi.nlm.nih.gov/pubmed/33014268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2739459
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