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The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells

ABSTRACT: Acidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both “aerobic” and “anaerobic” glycolysis of differently adapted cancer cells, with the final product lactic acid being responsible of the extracellular acidi...

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Detalhes bibliográficos
Publicado no:J Mol Med (Berl)
Main Authors: Andreucci, Elena, Peppicelli, Silvia, Ruzzolini, Jessica, Bianchini, Francesca, Biagioni, Alessio, Papucci, Laura, Magnelli, Lucia, Mazzanti, Benedetta, Stecca, Barbara, Calorini, Lido
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525286/
https://ncbi.nlm.nih.gov/pubmed/32803272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-020-01959-y
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