The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells

ABSTRACT: Acidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both “aerobic” and “anaerobic” glycolysis of differently adapted cancer cells, with the final product lactic acid being responsible of the extracellular acidi...

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Bibliografiska uppgifter
I publikationen:J Mol Med (Berl)
Huvudupphovsmän: Andreucci, Elena, Peppicelli, Silvia, Ruzzolini, Jessica, Bianchini, Francesca, Biagioni, Alessio, Papucci, Laura, Magnelli, Lucia, Mazzanti, Benedetta, Stecca, Barbara, Calorini, Lido
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2020
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525286/
https://ncbi.nlm.nih.gov/pubmed/32803272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-020-01959-y
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