Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction–in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Preclinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524792/
https://ncbi.nlm.nih.gov/pubmed/33015415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.07.009
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados