Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

The tight junction protein claudin-2 is upregulated in disease. Although many studies have linked intestinal barrier loss to local and systemic disease, these have relied on macromolecular probes. In vitro analyses show, however, that these probes cannot be accommodated by size- and charge-selective...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Raju, Preeti, Shashikanth, Nitesh, Tsai, Pei-Yun, Pongkorpsakol, Pawin, Chanez-Paredes, Sandra, Steinhagen, Peter R., Kuo, Wei-Ting, Singh, Gurminder, Tsukita, Sachiko, Turner, Jerrold R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524482/
https://ncbi.nlm.nih.gov/pubmed/32516134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138697
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