Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

The tight junction protein claudin-2 is upregulated in disease. Although many studies have linked intestinal barrier loss to local and systemic disease, these have relied on macromolecular probes. In vitro analyses show, however, that these probes cannot be accommodated by size- and charge-selective...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Raju, Preeti, Shashikanth, Nitesh, Tsai, Pei-Yun, Pongkorpsakol, Pawin, Chanez-Paredes, Sandra, Steinhagen, Peter R., Kuo, Wei-Ting, Singh, Gurminder, Tsukita, Sachiko, Turner, Jerrold R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524482/
https://ncbi.nlm.nih.gov/pubmed/32516134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138697
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