Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

Claudin-2 is highly expressed in tight junctions of mouse renal proximal tubules, which possess a leaky epithelium whose unique permeability properties underlie their high rate of NaCl reabsorption. To investigate the role of claudin-2 in paracellular NaCl transport in this nephron segment, we gener...

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Main Authors: Muto, Shigeaki, Hata, Masaki, Taniguchi, Junichi, Tsuruoka, Shuichi, Moriwaki, Kazumasa, Saitou, Mitinori, Furuse, Kyoko, Sasaki, Hiroyuki, Fujimura, Akio, Imai, Masashi, Kusano, Eiji, Tsukita, Shoichiro, Furuse, Mikio
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867900/
https://ncbi.nlm.nih.gov/pubmed/20385797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912901107
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