Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma

BACKGROUND: Diffuse midline gliomas (DMG), including brainstem diffuse intrinsic pontine glioma (DIPG), are incurable pediatric high-grade gliomas (pHGG). Mutations in the H3 histone tail (H3.1/3.3-K27M) are a feature of DIPG, rendering them therapeutically sensitive to small-molecule inhibition of...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Bailey, Cavan P, Figueroa, Mary, Gangadharan, Achintyan, Yang, Yanwen, Romero, Megan M, Kennis, Bridget A, Yadavilli, Sridevi, Henry, Verlene, Collier, Tiara, Monje, Michelle, Lee, Dean A, Wang, Linghua, Nazarian, Javad, Gopalakrishnan, Vidya, Zaky, Wafik, Becher, Oren J, Chandra, Joya
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523459/
https://ncbi.nlm.nih.gov/pubmed/32166329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa058
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