EXTH-75. IN VITRO AND IN VIVO EFFICACY OF COMBINATORIAL INHIBITION OF LSD1 AND HDACS IN PATIENT DERIVED GLIOBLASTOMA STEM CELL MODELS

Inhibitors of histone deacetylases (HDACi) have been tested in glioblastoma (GBM), however, single agent clinical efficacy has not been proven, prompting study of combinatorial approaches. A rational HDACi combination strategy is with inhibition of LSD1, lysine specific demethylase 1, a histone deme...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Gangadharan, Achintyan, Grasse, Leslie, Espejo, Alexsandra, Ezhilarasan, Ravesanker, Collier, Tiara, Henry, Verlene, Gumin, Joy, Sulman, Erik, Lang, Frederick, Chandra, Joya
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Preclinical Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650876/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.429
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