DDRE-31. EVALUATION OF HIGHLY POTENT AND SELECTIVE SINGLE-MOLECULE DUAL EGFR/PI3K INHIBITORS IN ADULT AND PEDIATRIC HIGH-GRADE GLIOMA

High grade gliomas (HGG) carry poor prognosis with median survival rates under 15 months post diagnosis. Due to dysregulation of kinase signaling pathways within these tumors, targeted kinase inhibition has been considered as a promising clinical strategy. However in HGG, many single-agent inhibitor...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Gangadharan, Achintyan, Sun, Yusha, Bailey, Cavan, Carter, Trever, Espejo, Alexsandra, Whitehead, Christopher, Leopold, Judith, Chandra, Joya
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Discovery, Drug Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651413/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.276
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