Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma

BACKGROUND: Diffuse midline gliomas (DMG), including brainstem diffuse intrinsic pontine glioma (DIPG), are incurable pediatric high-grade gliomas (pHGG). Mutations in the H3 histone tail (H3.1/3.3-K27M) are a feature of DIPG, rendering them therapeutically sensitive to small-molecule inhibition of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Bailey, Cavan P, Figueroa, Mary, Gangadharan, Achintyan, Yang, Yanwen, Romero, Megan M, Kennis, Bridget A, Yadavilli, Sridevi, Henry, Verlene, Collier, Tiara, Monje, Michelle, Lee, Dean A, Wang, Linghua, Nazarian, Javad, Gopalakrishnan, Vidya, Zaky, Wafik, Becher, Oren J, Chandra, Joya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523459/
https://ncbi.nlm.nih.gov/pubmed/32166329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa058
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge