Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems

Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for B...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Joshi, Piyush, Bodnya, Caroline, Rasmussen, Megan L., Romero-Morales, Alejandra I., Bright, Anna, Gama, Vivian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519160/
https://ncbi.nlm.nih.gov/pubmed/32978370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03002-x
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