A genome-wide pooled shRNA screen identifies PPP2R2A as a predictive biomarker for the response to ATR and CHK1 inhibitors

There is currently a lack of precise predictive biomarkers for patient selection in clinical trials of inhibitors targeting replication stress (RS) response proteins ATR and CHK1. The objective of this study was to identify novel predictive biomarkers for the response to these agents in treating non...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Qiu, Zhaojun, Fa, Pengyan, Liu, Tao, Prasad, Chandra B., Ma, Shanhuai, Hong, Zhipeng, Chan, Ernest R., Wang, Hongbing, Li, Zaibo, He, Kai, Wang, Qi-En, Williams, Terence M., Yan, Chunhong, Sizemore, Steven T., Narla, Goutham, Zhang, Junran
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518641/
https://ncbi.nlm.nih.gov/pubmed/32522823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0057
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