RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells

PURPOSE: 1) To investigate expression of the E3 ligase, RNF126, in human invasive breast cancer (BC) and its links with BC outcomes. 2) To test the hypothesis that RNF126 determines the efficacy of inhibitors targeting the cell cycle checkpoint kinase, CHK1. EXPERIMENTAL DESIGN: A retrospective anal...

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Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Yang, Xiaosong, Pan, You, Qiu, Zhaojun, Du, Zhanwen, Zhang, Yao, Fa, Pengyan, Gorityala, Shashank, Ma, Shanhuai, Li, Shunqiang, Chen, Ceshi, Wang, Hongbing, Xu, Yan, Yan, Chunhong, Ruth, Keri, Ma, Zhefu, Zhang, Junran
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884735/
https://ncbi.nlm.nih.gov/pubmed/29326282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2242
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