RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells

PURPOSE: 1) To investigate expression of the E3 ligase, RNF126, in human invasive breast cancer (BC) and its links with BC outcomes. 2) To test the hypothesis that RNF126 determines the efficacy of inhibitors targeting the cell cycle checkpoint kinase, CHK1. EXPERIMENTAL DESIGN: A retrospective anal...

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Publicat a:Clin Cancer Res
Autors principals: Yang, Xiaosong, Pan, You, Qiu, Zhaojun, Du, Zhanwen, Zhang, Yao, Fa, Pengyan, Gorityala, Shashank, Ma, Shanhuai, Li, Shunqiang, Chen, Ceshi, Wang, Hongbing, Xu, Yan, Yan, Chunhong, Ruth, Keri, Ma, Zhefu, Zhang, Junran
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884735/
https://ncbi.nlm.nih.gov/pubmed/29326282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2242
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