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Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

The recently renewed interest in scientific rigor and reproducibility is of critical importance for both scientists developing new targeted small-molecule inhibitors and those employing these molecule in cellular studies, alike. While off-target effects are commonly considered as limitations for any...

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Publicado en:Cancer Biol Ther
Main Authors: Hengst, Jeremy A., Dick, Taryn E., Smith, Charles D., Yun, Jong K.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515464/
https://ncbi.nlm.nih.gov/pubmed/32835586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2020.1798696
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