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Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization

Our sphingosine kinase inhibitor (SKI) optimization studies originated with the optimization of the SKI-I chemotype by replacement of the substituted benzyl rings with substituted phenyl rings giving rise to the discovery of SKI-178. We have recently reported that SKI-178 is a dual-targeted inhibito...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Hengst, Jeremy A., Hegde, Shailaja, Paulson, Robert F., Yun, Jong K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541634/
https://ncbi.nlm.nih.gov/pubmed/32736077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127453
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