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SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models
AIM: To further characterize the selectivity, mechanism-of-action and therapeutic efficacy of the novel small molecule inhibitor, SKI-178. METHODS: Using the state-of-the-art Cellular Thermal Shift Assay (CETSA) technique to detect “direct target engagement” of proteins intact cells, in vitro and in...
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| izdano v: | Cancer Transl Med |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5590228/ https://ncbi.nlm.nih.gov/pubmed/28890935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/ctm.ctm_7_17 |
| Oznake: |
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