SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

AIM: To further characterize the selectivity, mechanism-of-action and therapeutic efficacy of the novel small molecule inhibitor, SKI-178. METHODS: Using the state-of-the-art Cellular Thermal Shift Assay (CETSA) technique to detect “direct target engagement” of proteins intact cells, in vitro and in...

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Publicado no:Cancer Transl Med
Main Authors: Hengst, Jeremy A., Dick, Taryn E., Sharma, Arati, Doi, Kenichiro, Hegde, Shailaja, Tan, Su-Fern, Geffert, Laura M., Fox, Todd E., Sharma, Arun K., Desai, Dhimant, Amin, Shantu, Kester, Mark, Loughran, Thomas P., Paulson, Robert F., Claxton, David F., Wang, Hong-Gang, Yun, Jong K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590228/
https://ncbi.nlm.nih.gov/pubmed/28890935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/ctm.ctm_7_17
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