The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers

Various forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful against a subset of ALK(+) tumours, clinical resistance to this drug has been well recognized and the mechanism of this phen...

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Vydáno v:Sci Rep
Hlavní autoři: Alshareef, Abdulraheem, Zhang, Hai-Feng, Huang, Yung-Hsing, Wu, Chengsheng, Zhang, Jing Dong, Wang, Peng, El-Sehemy, Ahmed, Fares, Mohamed, Lai, Raymond
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027386/
https://ncbi.nlm.nih.gov/pubmed/27641368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33710
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