Application of the Cellular Thermal Shift Assay (CETSA) to validate drug target engagement in platelets
Small molecule drugs play a major role in the study of human platelets. Effective action of a drug requires it to bind to one or more targets within the platelet (target engagement). However, although in vitro assays with isolated proteins can be used to determine drug affinity to these targets, add...
Guardado en:
| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis Group
2024-12-01
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| Colección: | Platelets |
| Materias: | |
| Acceso en línea: | https://www.tandfonline.com/doi/10.1080/09537104.2024.2354833 |
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