Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

BACKGROUND: Tumour mutational status is an important determinant of the response of metastatic colorectal cancer to targeted treatments. However, the genotype of the tissue obtained at the time of diagnosis might not accurately represent tumour genotype after multiple lines of treatment. This retros...

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Detalhes bibliográficos
Publicado no:Lancet Oncol
Main Authors: Tabernero, Josep, Lenz, Heinz-Josef, Siena, Salvatore, Sobrero, Alberto, Falcone, Alfredo, Ychou, Marc, Humblet, Yves, Bouché, Olivier, Mineur, Laurent, Barone, Carlo, Adenis, Antoine, Yoshino, Takayuki, Goldberg, Richard M, Sargent, Daniel J, Wagner, Andrea, Laurent, Dirk, Teufel, Michael, Jeffers, Michael, Grothey, Axel, Van Cutsem, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513622/
https://ncbi.nlm.nih.gov/pubmed/26184520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(15)00138-2
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