Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells in vivo; however, with the expanding repertoire of CRISPR/Cas endonucleases, it is n...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Li, Fan, Wing, Kristof, Wang, Jiang-Hui, Luu, Chi D., Bender, James A., Chen, Jinying, Wang, Qi, Lu, Qinyi, Nguyen Tran, Minh Thuan, Young, Kaylene M., Wong, Raymond C. B., Pébay, Alice, Cook, Anthony L., Hung, Sandy S. C., Liu, Guei-Sheung, Hewitt, Alex W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511709/
https://ncbi.nlm.nih.gov/pubmed/33132845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.570917
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