Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research and clinical uses of these enzymes. We report the d...

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Publicado no:J Am Chem Soc
Main Authors: Rouet, Romain, Thuma, Benjamin A., Roy, Marc D., Lintner, Nathanael G., Rubitski, David M., Finley, James E., Wisniewska, Hanna M., Mendonsa, Rima, Hirsh, Ariana, de Oñate, Lorena, Barrón, Joan Compte, McLellan, Thomas J., Bellenger, Justin, Feng, Xidong, Varghese, Alison, Chrunyk, Boris A., Borzilleri, Kris, Hesp, Kevin D., Zhou, Kaihong, Ma, Nannan, Tu, Meihua, Dullea, Robert, McClure, Kim F., Wilson, Ross C., Liras, Spiros, Mascitti, Vincent, Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002863/
https://ncbi.nlm.nih.gov/pubmed/29668265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b01551
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