Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structures of ligand-bound ASGPR. This analogue was used...

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Publicado no:J Am Chem Soc
Main Authors: Sanhueza, Carlos A., Baksh, Michael M., Thuma, Benjamin, Roy, Marc D., Dutta, Sanjay, Préville, Cathy, Chrunyk, Boris A., Beaumont, Kevin, Dullea, Robert, Ammirati, Mark, Liu, Shenping, Gebhard, David, Finley, James E., Salatto, Christopher T., King-Ahmad, Amanda, Stock, Ingrid, Atkinson, Karen, Reidich, Benjamin, Lin, Wen, Kumar, Rajesh, Tu, Meihua, Menhaji-Klotz, Elnaz, Price, David A., Liras, Spiros, Finn, M. G., Mascitti, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991140/
https://ncbi.nlm.nih.gov/pubmed/28230359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12964
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