Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structures of ligand-bound ASGPR. This analogue was used...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Sanhueza, Carlos A., Baksh, Michael M., Thuma, Benjamin, Roy, Marc D., Dutta, Sanjay, Préville, Cathy, Chrunyk, Boris A., Beaumont, Kevin, Dullea, Robert, Ammirati, Mark, Liu, Shenping, Gebhard, David, Finley, James E., Salatto, Christopher T., King-Ahmad, Amanda, Stock, Ingrid, Atkinson, Karen, Reidich, Benjamin, Lin, Wen, Kumar, Rajesh, Tu, Meihua, Menhaji-Klotz, Elnaz, Price, David A., Liras, Spiros, Finn, M. G., Mascitti, Vincent
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991140/
https://ncbi.nlm.nih.gov/pubmed/28230359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12964
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