Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells in vivo; however, with the expanding repertoire of CRISPR/Cas endonucleases, it is n...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Cell Neurosci
Auteurs principaux: Li, Fan, Wing, Kristof, Wang, Jiang-Hui, Luu, Chi D., Bender, James A., Chen, Jinying, Wang, Qi, Lu, Qinyi, Nguyen Tran, Minh Thuan, Young, Kaylene M., Wong, Raymond C. B., Pébay, Alice, Cook, Anthony L., Hung, Sandy S. C., Liu, Guei-Sheung, Hewitt, Alex W.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511709/
https://ncbi.nlm.nih.gov/pubmed/33132845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.570917
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