Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

DNA replication is needed to duplicate a cell’s genome in S phase and segregate it during cell division. Previous work in Leishmania detected DNA replication initiation at just a single region in each chromosome, an organisation predicted to be insufficient for complete genome duplication within S p...

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Udgivet i:eLife
Main Authors: Damasceno, Jeziel Dener, Marques, Catarina A, Beraldi, Dario, Crouch, Kathryn, Lapsley, Craig, Obonaga, Ricardo, Tosi, Luiz RO, McCulloch, Richard
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511235/
https://ncbi.nlm.nih.gov/pubmed/32897188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58030
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