Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9–1–1 complex in the maintenance of the plastic genome of Leishmania

Leishmania species are protozoan parasites whose remarkably plastic genome limits the establishment of effective genetic manipulation and leishmaniasis treatment. The strategies used by Leishmania to maintain its genome while allowing variability are not fully understood. Here, we used DiCre-mediate...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Damasceno, Jeziel D, Obonaga, Ricardo, Silva, Gabriel L A, Reis-Cunha, João L, Duncan, Samuel M, Bartholomeu, Daniella C, Mottram, Jeremy C, McCulloch, Richard, Tosi, Luiz R O
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294564/
https://ncbi.nlm.nih.gov/pubmed/30380080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1017
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