Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation

Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC). Why eukaryotes evolved a multisubunit initiator, an...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Marques, Catarina A., Tiengwe, Calvin, Lemgruber, Leandro, Damasceno, Jeziel D., Scott, Alan, Paape, Daniel, Marcello, Lucio, McCulloch, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889932/
https://ncbi.nlm.nih.gov/pubmed/26951375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw147
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