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Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania
Gamma-glutamylcysteine synthetase encoded by GSH1 is the rate-limiting enzyme in the biosynthesis of glutathione and trypanothione in Leishmania. Attempts to generate GSH1 null mutants by gene disruption failed in Leishmania infantum. Removal of even a single allele invariably led to the generation...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2011
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177219/ https://ncbi.nlm.nih.gov/pubmed/21693561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr494 |
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