Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures

INTRODUCTION: Selecting individuals at high risk of Alzheimer's disease (AD) dementia and using the most sensitive outcome measures are important aspects of trial design. METHODS: We divided participants from Alzheimer's Disease Neuroimaging Initiative at the 50th percentile of the predict...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Alzheimers Dement (N Y)
Main Authors: Banks, Sarah J., Qiu, Yuqi, Fan, Chun Chieh, Dale, Anders M., Zou, Jingjing, Askew, Brianna, Feldman, Howard H.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507583/
https://ncbi.nlm.nih.gov/pubmed/32999917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12071
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