Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues

This study investigated the role of CDK4 in the oxidative metabolism of brown adipose tissue (BAT). BAT from Cdk4 (−/−) mice exhibited fewer lipids and increased mitochondrial volume and expression of canonical thermogenic genes, rendering these mice more resistant to cold exposure. Interestingly, t...

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Gepubliceerd in:EMBO Rep
Hoofdauteurs: Castillo‐Armengol, Judit, Barquissau, Valentin, Geller, Sarah, Ji, Honglei, Severi, Ilenia, Venema, Wiebe, Fenandez, Eric Aria, Moret, Catherine, Huber, Katharina, Leal‐Esteban, Lucia C, Nasrallah, Anita, Martinez‐Carreres, Laia, Niederhäuser, Guy, Seoane‐Collazo, Patricia, Lagarrigue, Sylviane, López, Miguel, Giordano, Antonio, Croizier, Sophie, Thorens, Bernard, Lopez‐Mejia, Isabel C, Fajas, Lluis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507572/
https://ncbi.nlm.nih.gov/pubmed/32657019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949807
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