Ciliary Neurotrophic Factor Acts on Distinctive Hypothalamic Arcuate Neurons and Promotes Leptin Entry Into and Action on the Mouse Hypothalamus

In humans and experimental animals, the administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight. To gain further insights into the mechanism(s) underlying its satiety effect, we: (i) evaluated the CNTF-dependent activation of the Janus kinase 2 (JAK2) and signal tran...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Venema, Wiebe, Severi, Ilenia, Perugini, Jessica, Di Mercurio, Eleonora, Mainardi, Marco, Maffei, Margherita, Cinti, Saverio, Giordano, Antonio
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cellular Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253709/
https://ncbi.nlm.nih.gov/pubmed/32528252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00140
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