Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues

This study investigated the role of CDK4 in the oxidative metabolism of brown adipose tissue (BAT). BAT from Cdk4 (−/−) mice exhibited fewer lipids and increased mitochondrial volume and expression of canonical thermogenic genes, rendering these mice more resistant to cold exposure. Interestingly, t...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Castillo‐Armengol, Judit, Barquissau, Valentin, Geller, Sarah, Ji, Honglei, Severi, Ilenia, Venema, Wiebe, Fenandez, Eric Aria, Moret, Catherine, Huber, Katharina, Leal‐Esteban, Lucia C, Nasrallah, Anita, Martinez‐Carreres, Laia, Niederhäuser, Guy, Seoane‐Collazo, Patricia, Lagarrigue, Sylviane, López, Miguel, Giordano, Antonio, Croizier, Sophie, Thorens, Bernard, Lopez‐Mejia, Isabel C, Fajas, Lluis
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507572/
https://ncbi.nlm.nih.gov/pubmed/32657019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949807
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