Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues

This study investigated the role of CDK4 in the oxidative metabolism of brown adipose tissue (BAT). BAT from Cdk4 (−/−) mice exhibited fewer lipids and increased mitochondrial volume and expression of canonical thermogenic genes, rendering these mice more resistant to cold exposure. Interestingly, t...

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Udgivet i:EMBO Rep
Main Authors: Castillo‐Armengol, Judit, Barquissau, Valentin, Geller, Sarah, Ji, Honglei, Severi, Ilenia, Venema, Wiebe, Fenandez, Eric Aria, Moret, Catherine, Huber, Katharina, Leal‐Esteban, Lucia C, Nasrallah, Anita, Martinez‐Carreres, Laia, Niederhäuser, Guy, Seoane‐Collazo, Patricia, Lagarrigue, Sylviane, López, Miguel, Giordano, Antonio, Croizier, Sophie, Thorens, Bernard, Lopez‐Mejia, Isabel C, Fajas, Lluis
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507572/
https://ncbi.nlm.nih.gov/pubmed/32657019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949807
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