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Combined Protein- and Ligand-Observed NMR Workflow to Screen Fragment Cocktails against Multiple Proteins: A Case Study Using Bromodomains
As fragment-based drug discovery has become mainstream, there has been an increase in various screening methodologies. Protein-observed (19)F (PrOF) NMR and (1)H CPMG NMR are two fragment screening assays that have complementary advantages. Here, we sought to combine these two NMR-based assays into...
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| 發表在: | Molecules |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7504435/ https://ncbi.nlm.nih.gov/pubmed/32872491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25173949 |
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