Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma

Glioblastoma multiforme involves glioma stem cells (GSCs) that are resistant to various therapeutic approaches. Here, we studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2 (CCL2), C-X-C ligand 10 (C...

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Publicado en:Sci Rep
Main Authors: Shono, Kenji, Yamaguchi, Izumi, Mizobuchi, Yoshifumi, Kagusa, Hiroshi, Sumi, Akiko, Fujihara, Toshitaka, Nakajima, Kohei, Kitazato, Keiko T., Matsuzaki, Kazuhito, Saya, Hideyuki, Takagi, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499211/
https://ncbi.nlm.nih.gov/pubmed/32943658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71857-3
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