Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma

Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remai...

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Vydáno v:J Neurooncol
Hlavní autoři: Sato, Aya, Mizobuchi, Yoshifumi, Nakajima, Kohei, Shono, Kenji, Fujihara, Toshitaka, Kageji, Teruyoshi, Kitazato, Keiko, Matsuzaki, Kazuhito, Mure, Hideo, Kuwayama, Kazuyuki, Sumi, Akiko, Saya, Hideyuki, Sampetrean, Oltea, Nagahirao, Shinji
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2017
Témata:
Laboratory Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763415/
https://ncbi.nlm.nih.gov/pubmed/28283800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-017-2380-5
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