Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway

Glioblastoma (GBM) has high mortality rates because of extreme therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high...

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Pubblicato in:Sci Rep
Autori principali: Shono, Kenji, Mizobuchi, Yoshifumi, Yamaguchi, Izumi, Nakajima, Kohei, Fujiwara, Yuri, Fujihara, Toshitaka, Kitazato, Keiko, Matsuzaki, Kazuhito, Uto, Yoshihiro, Sampetrean, Oltea, Saya, Hideyuki, Takagi, Yasushi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302615/
https://ncbi.nlm.nih.gov/pubmed/34301977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93896-0
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