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Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma

Glioblastoma multiforme involves glioma stem cells (GSCs) that are resistant to various therapeutic approaches. Here, we studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2 (CCL2), C-X-C ligand 10 (C...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shono, Kenji, Yamaguchi, Izumi, Mizobuchi, Yoshifumi, Kagusa, Hiroshi, Sumi, Akiko, Fujihara, Toshitaka, Nakajima, Kohei, Kitazato, Keiko T., Matsuzaki, Kazuhito, Saya, Hideyuki, Takagi, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499211/
https://ncbi.nlm.nih.gov/pubmed/32943658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71857-3
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