EXTH-06. DOWN-REGULATION OF PD-L1 VIA FKBP5 LOWERED BY A CYCLOOXYGENASE-2 INHIBITOR IN GSCs AND GBM CELLS MAY BE ATTRIBUTABLE TO ENHANCE ANTITUMOR EFFECTS OF IMMUNOTHERAPY

BACKGROUND: Antitumor therapies targeting programmed cell death-1 (PD-1)/its ligand-1 (PD-L1) are influential at present stage. However, in glioblastoma (GBM), the expression of PD-L1 is variable and the role of anti-PD-1 antibody therapy is still unclear. The high expression of PD-L1 affects cell p...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Yamaguchi, Izumi, Nakajima, Kohei, Shono, Kenji, Mizobuchi, Yoshifumi, Fujihara, Toshitaka, Kitazato, Keiko, Takagi, Yasushi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847806/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.340
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