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Structure of two G-quadruplexes in equilibrium in the KRAS promoter
KRAS is one of the most mutated oncogenes and still considered an undruggable target. An alternative strategy would consist in targeting its gene rather than the protein, specifically the formation of G-quadruplexes (G4) in its promoter. G4 are secondary structures implicated in biological processes...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7498360/ https://ncbi.nlm.nih.gov/pubmed/32432667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa387 |
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