High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4). G4s can coexist with canonical duplex DNA in the human genome and have been suggested to suppress gene transcription, and much attention has ther...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Kerkour, Abdelaziz, Marquevielle, Julien, Ivashchenko, Stefaniia, Yatsunyk, Liliya A., Mergny, Jean-Louis, Salgado, Gilmar F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427283/
https://ncbi.nlm.nih.gov/pubmed/28330874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781906
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