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Structure of two G-quadruplexes in equilibrium in the KRAS promoter
KRAS is one of the most mutated oncogenes and still considered an undruggable target. An alternative strategy would consist in targeting its gene rather than the protein, specifically the formation of G-quadruplexes (G4) in its promoter. G4 are secondary structures implicated in biological processes...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7498360/ https://ncbi.nlm.nih.gov/pubmed/32432667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa387 |
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