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A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

Helicases, enzymes that unwind DNA or RNA structure, are present in the cell nucleus and in the mitochondrion. Although the majority of the helicases unwind DNA or RNA duplexes, some of these proteins are known to resolve unusual structures such as G-quadruplexes (G4) in vitro. G4 may form stable ba...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Mendoza, Oscar, Gueddouda, Nassima Meriem, Boulé, Jean-Baptiste, Bourdoncle, Anne, Mergny, Jean-Louis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477640/
https://ncbi.nlm.nih.gov/pubmed/25765657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv193
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