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A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

Helicases, enzymes that unwind DNA or RNA structure, are present in the cell nucleus and in the mitochondrion. Although the majority of the helicases unwind DNA or RNA duplexes, some of these proteins are known to resolve unusual structures such as G-quadruplexes (G4) in vitro. G4 may form stable ba...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Mendoza, Oscar, Gueddouda, Nassima Meriem, Boulé, Jean-Baptiste, Bourdoncle, Anne, Mergny, Jean-Louis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477640/
https://ncbi.nlm.nih.gov/pubmed/25765657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv193
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