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Fluorescence-based duplex–quadruplex competition test to screen for telomerase RNA quadruplex ligands

RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5′-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a key structural element for thi...

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Detalhes bibliográficos
Main Authors: Lacroix, Laurent, Séosse, Aurélie, Mergny, Jean-Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045579/
https://ncbi.nlm.nih.gov/pubmed/21106496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1199
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