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Fluorescence-based duplex–quadruplex competition test to screen for telomerase RNA quadruplex ligands
RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5′-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a key structural element for thi...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3045579/ https://ncbi.nlm.nih.gov/pubmed/21106496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1199 |
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