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G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription

In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine–polypyrimidine element (NHPPE) that is essential for transcription. An interesting feature of the polypurine G-rich strand of NHPPE is its ability to assume an unusual DNA structure that, according to cir...

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Autors principals: Cogoi, Susanna, Xodo, Luigi E.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459413/
https://ncbi.nlm.nih.gov/pubmed/16687659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl286
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