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HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property

The HRAS promoter contains immediately upstream of the transcription start site two neighboring G-elements, each capable of folding into a G-quadruplex structure. We have previously found that these G-quadruplexes bind to the zinc-finger transcription factors MAZ and Sp1. In the present study we hav...

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Détails bibliographiques
Auteurs principaux: Cogoi, Susanna, Shchekotikhin, Andrey E., Xodo, Luigi E.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117790/
https://ncbi.nlm.nih.gov/pubmed/25013182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku574
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