Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

The human KRAS proto-oncogene contains a critical nuclease hypersensitive element (NHE) upstream of the major transcription initiation site. In this article, we demonstrate by primer-extension experiments, PAGE, chemical footprinting, CD, UV and FRET experiments that the G-rich strand of NHE (32R) f...

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Bibliographic Details
Main Authors: Cogoi, Susanna, Paramasivam, Manikandan, Spolaore, Barbara, Xodo, Luigi E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441797/
https://ncbi.nlm.nih.gov/pubmed/18490377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn120
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