A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex

The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is the sole target of broadly neutralizing antibodies (bnAbs). Several mechanisms, such as the acquisition of mutations, variability of the loop length, and alterations in the glycan pattern, are employed by the virus to...

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Vydáno v:J Virol
Hlavní autoři: Mishra, Nitesh, Sharma, Shaifali, Dobhal, Ayushman, Kumar, Sanjeev, Chawla, Himanshi, Singh, Ravinder, Das, Bimal Kumar, Kabra, Sushil Kumar, Lodha, Rakesh, Luthra, Kalpana
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495384/
https://ncbi.nlm.nih.gov/pubmed/32669335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00814-20
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