A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex

The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is the sole target of broadly neutralizing antibodies (bnAbs). Several mechanisms, such as the acquisition of mutations, variability of the loop length, and alterations in the glycan pattern, are employed by the virus to...

詳細記述

保存先:
書誌詳細
出版年:J Virol
主要な著者: Mishra, Nitesh, Sharma, Shaifali, Dobhal, Ayushman, Kumar, Sanjeev, Chawla, Himanshi, Singh, Ravinder, Das, Bimal Kumar, Kabra, Sushil Kumar, Lodha, Rakesh, Luthra, Kalpana
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2020
主題:
Genetic Diversity and Evolution
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495384/
https://ncbi.nlm.nih.gov/pubmed/32669335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00814-20
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